Complex Segregation Analysis of Canine Hip Dysplasia in German Shepherd Dogs

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Hip dysplasia: coxafemoral abnormalities in neonatal German Shepherd dogs.

1. Hip dysplasia in German Shepherd Dogs, half of which could be expected to develop detectable hip dysplasia by 1 yr of age, was not observed at birth. This was based on the disection and gross examination of the pelves of eighty-seven neonatal pups. Minor ligamentous changes which may suggest beginning hip dysplasia were seen in three pelves from pups 30 days old. The round ligament seems to ...

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Heritability and Phenotypic Variation of Canine Hip Dysplasia Radiographic Traits in a Cohort of Australian German Shepherd Dogs

Canine Hip Dysplasia (CHD) is a common, painful and debilitating orthopaedic disorder of dogs with a partly genetic, multifactorial aetiology. Worldwide, potential breeding dogs are evaluated for CHD using radiographically based screening schemes such as the nine ordinally-scored British Veterinary Association Hip Traits (BVAHTs). The effectiveness of selective breeding based on screening resul...

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Estimated Breeding Values for Canine Hip Dysplasia Radiographic Traits in a Cohort of Australian German Shepherd Dogs

Canine hip dysplasia (CHD) is a serious and common musculoskeletal disease of pedigree dogs and therefore represents both an important welfare concern and an imperative breeding priority. The typical heritability estimates for radiographic CHD traits suggest that the accuracy of breeding dog selection could be substantially improved by the use of estimated breeding values (EBVs) in place of sel...

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Identification and Validation of Quantitative Trait Loci (QTL) for Canine Hip Dysplasia (CHD) in German Shepherd Dogs

Canine hip dysplasia (CHD) is the most common hereditary skeletal disorder in dogs. To identify common alleles associated with CHD, we genotyped 96 German Shepherd Dogs affected by mild, moderate and severe CHD and 96 breed, sex, age and birth year matched controls using the Affymetrix canine high density SNP chip. A mixed linear model analysis identified five SNPs associated with CHD scores on...

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ژورنال

عنوان ژورنال: Journal of Heredity

سال: 2005

ISSN: 1465-7333,0022-1503

DOI: 10.1093/jhered/esi128